King's College London

Postdoctoral Research Associate

Reference: THW/17/059639/000249
Salary Details: £32,958 per annum
Allowances: Plus £2,623 LWA
Contract Type: Temporary/Fixed term
Contract Term: Full time

We are seeking a highly motivated Postdoctoral Research Associate to join the Department of Basic and Clinical Neuroscience at the Institute of Psychiatry, Psychology & Neuroscience, King’s College London. The post is funded by the Alzheimer’s Society for three years. We have developed a new mouse model that we are using to investigate molecular mechanisms underlying the development of neurodegenerative diseases, such as Alzheimer’s disease and related disorders (Bondulich et al. 2016, Brain, 139, 2290). In particular, we are examining the influence of tau on disease mechanisms and cognitive processes. The aim of this project is to establish primary neuronal cultures from this tauopathy model and begin to test the adverse effects of expressing a disease-associated tau fragment. We have shown previously that tau is released by neurons and that this process is critically dependent on both calcium and neuronal activity. We want to test whether expression of a tau fragment in neurons adversely affects basal and stimulated tau release. We will also examine the influence of the tau fragment on synaptic proteins and the development of dendritic spines in cultured neurons, which is important for disease pathogenesis in dementia.

Experience in working with transgenic mouse models and primary neurons using advanced microscopy, biochemical, cell and molecular biology approaches would be advantageous. A good knowledge of defective signaling processes in dementia and related disorders is also required for this post. The successful applicants will join established research groups headed by Professor Diane Hanger: http://www.kcl.ac.uk/ioppn/depts/bcn/Our-research/Neurodegeneration/diane-hanger-dementia-tauopathies/Index.aspx
and Dr Wendy Noble: http://www.kcl.ac.uk/ioppn/depts/bcn/Our-research/Neurodegeneration/wendy-noble-neurodegeneration/Index.aspx

This post will be Fixed Term Contract for 3 years.

This is a Full-time post.

The salary will be paid at Grade 6, £32,958 per annum, plus £2,623 per annum London Allowance.

The deadline for applications is midnight on 23 March 2017.

The selection process will include a presentation and a panel interview. Interviews are expected to be held early April 2017.

Closing date: 23 March 2017

Attachments:
Job Pack | (Word Document 276k)

If you have questions about this role, please contact: Professor Diane Hanger, Email: diane.hanger@kcl.ac.uk,

Application form:


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