King's College London

Research Associate or Research Assistant (Bioinformatician in gene regulation)

Reference: THW/18/059639/000733
Salary Details: £28,098 to £39,992 per annum
Allowances: plus £2,923 per annum London
Contract Type: Temporary/Fixed term
Contract Term: Full time

The salary will be paid at Grade 6 for Research Associates, £33,518 to £39,992 per annum, plus £2,923 per annum London Allowance; at Grade 5 for Research Assistant, £28,098 to £32,548 per annum, plus £2,923 per annum London Allowance.

This post will be a Fixed Term Contract for 1 year

The purpose of this post is to develop and expedite projects aimed at characterizing transcription factors/epigenetic modifying enzymes in normal and leukemic stem cell development using newly developed disease models in the lab, mostly based on conditional KO/KI approaches and our humanized models. We are seeking a highly motivated computational biologist to work on transcriptional and epigenetic regulation in normal and leukemic stem cells, a close collaborative programme between the Leukaemia and Stem Cell Biology Group led by Professor So at King’s College London and the Computational Regulatory Genomics Group led by Prof. Boris Lenhard at Imperial College London.

Regulation of transcriptional programmes for gene expression is key for normal and cancer stem cell development. Transcription factors and their associated epigenetic modifying enzymes are frequently deregulated or even mutated in human acute myeloid leukemia (Zeisig et al., 2012, Cancer Cell). Over the years, our lab has focused on identification and characterization of key transcriptional and epigenetic networks critical for leukemia development (Kwok et al., 2006, Cancer Cell; Zeisig et al., 2007, Cancer Cell; Cheung et al., 2007, Nat Cell Biology; Arteaga et al., 2013, Cancer Cell; Esposito et al., 2015, Nature Medicine; Cheung et al., 2016, Cancer Cell). At the same time, in order to gain further insights into the cellular and biological functions of these factors in development, we studied and revealed a novel crosstalk between Bmi1 and Hoxa9 in regulating senescence in normal and leukemia stem cells (Smith et al., 2011, Cell Stem Cell) and also discovered essential function of canonical Wnt signalling in leukemia but normal stem cells (Yeung et al., 2010; Cancer Cell). Details about the lab can be found at www.ericso.org. Candidates are expected to have strong background and relevant publications in areas of hematopoietic stem cells and/or leukemia biology.

The initial contract is 1 year, but is renewable subject to the progress of the projects

The selection process will include competency based questions, a presentation, an assessment and a panel interview.
Interviews are scheduled to be held the week commencing

To apply for this role, please register to download and submit the specified application form.

Closing date: 13 July 2018

Attachments:
Job Pack | (Word Document 282k)

If you have questions about this role, please contact: Prof Eric So, Email: eric.so@kcl.ac.uk,

Application form:


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