King's College London

Research Associate (DRI) in the Department of Basic and Clinical Neuroscience

Reference: THW/18/059639/000787
Salary Details: Grade 6 : £33,518 to £36,613 per annum
Allowances: Plus £2,923 London Allowance
Contract Type: Temporary/Fixed term
Contract Term: Full time

We are seeking to appoint a postdoctoral neuroscientist to the King’s College London Dementia Research Institute (DRI), funded by the Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK. This is a national consortium focused on cutting-edge dementia research.

The primary research interest of the group involves understanding the pathophysiology of Alzheimer’s disease (AD). Central to this is the weakening of synaptic connections and ultimately their elimination, which is thought to correlate with disease severity. Synapse weakening is therefore fundamental in AD pathogenesis. Evidence suggests that changes to the synaptic expression of AMPA receptors are considered a major component of synaptic plasticity and synaptic connectivity, which are severely dysregulated by AD.

We have shown that specific signal cascades (e.g., amyloid-beta, caspase, GSK-3 and phosphorylation of tau) underlie synapse weakening and are necessary to induce weakening of AMPA receptor mediated excitatory synaptic transmission. The focus of this project is therefore to explore a key question: which factors modulate the cellular and molecular mechanisms of ‘synapse weakening’ during dementia-associated pathology.

The role will involve cell/molecular biology and biochemical techniques, multi-photon and super-resolution imaging, optogenetics and neurophysiology.

Closing date: 12 July 2018

Attachments:
Job Pack | (Word Document 275k)

If you have questions about this role, please contact: Professor Kei Cho, Email: kei.cho@kcl.ac.uk,

Application form:


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